Hydroxypropyl Methylcellulose Phthalic Ester-HPMCP
Product technical requirements:(accord to American drug USP24/NF19 standard) 1.Quality standard:
Specification item |
HP55(200731) |
HP55S(200731) |
Viscidity(10%,20±0.1℃) |
32-48 |
136-204 |
Loss on drying |
≤5.0% |
|
Ignition residue |
≤0.2% |
|
Chloride |
≤0.07% |
|
Arsenic |
≤2ppm |
|
Heavy metal |
≤0.001% |
|
Free phthalic acid |
≤1.0% |
|
Phthaloyl group |
27.0-35.0% |
|
Methoxyl |
18.0-22.0% |
|
Hydroxypropyl |
5.0-9.0% |
|
Key Characters:
1.Hydroxypropyl Methylcellulose Phthalic Ester has film formation.
2.Soluble ph value is lower than crylic acid resin.
3.HPMCP has good storage stability.
4.HPMCP is safe and non-toxic.
5.Strong coating plasticity
6.HPMCP can be used as enteric solubility film materials
7.HPMCP is one of the main ingredients for capsulae enterosolubilis
Properties
1.Appearance:flavorless white powder or granule. density:0.26-0.79g/cm3。
2.Specific gravity:1.28 softening point:200~210℃。
3.Surface Solubility:0.2-0.4fg/cm3
4.Organic solvent solubility:HP55 and HP55S can dissolve in organic solvents.
Use:Hydroxypropyl Methylcellulose Phthalic Ester can be enteric solubility film materials, and has good plasticity and film formations. It has good storage stability.
Preparation of coating solution:
1.Shroma:HP55 HP55S
Troche: 6-10% 5-8%
Granule: 5-7% 4-6%
2.All organic solvent:
Dichloromethane / Ethanol (1:1)
Acetone / Ethanol (1:1)
Ethanol / Water (8:2)
3.Solution method:add the container into a certain of solvent and put HPMCP to mix in equality slowly during mixing.
4.Dosage of HPMCP: 6-10% of film holders
Safety:Safe and non-toxic. Airproof environment to avoid form great dust.
Packing and Storage:Paper board drum lined with double-layer polyethylene plastic bag. 2kg/drum or 5 kg/drum. Store in cool, dry and ventilated and prevent drench, high temperature and light-shining.